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In a study on the efficacy and safety of catalpol in the treatment of postoperative patients with locally advanced colon cancer, patients treated with an intraperitoneal injection of 10 mg/kg catalpol twice a day for 12 weeks, monitoring patients appeared with adverse reactions of diarrhea, nausea, vomiting, gastrointestinal ulcers, allergy, constipation, alopecia, and peripheral neurotoxicity

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This is often closely intertwined with mast cell activation syndrome (MCAS), where accumulated toxins and chronic oxidative stress cause mast cells to become hyper-reactive, constantly degranulating and releasing histamine and other inflammatory mediators into the bloodstream