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This selectivity profile is what distinguishes FOXO4-DRI from broader cytotoxic agents and makes it the primary peptide tool for selective senescent cell elimination in the cellular senescence research field
The concern is theoretical and mechanistic: Dihexa's proposed action is potentiation of hepatocyte growth factor (HGF) signaling at the c-Met receptor, a growth, proliferation, and angiogenesis pathway that is dysregulated in several cancers
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