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In this specific cycle: 1 Hydrogen peroxide, a free radical and reactive oxygen species, is converted into water (harmless), and oxygen 2 Two molecules of reduced Glutathione [GSH (the active antioxidant form of glutathione)] are used by the Glutathione peroxidase enzyme to neutralize one molecule of hydrogen peroxide 3 NADPH is used by glutathione reductase enzyme to reduce ("recycle") glutathione disulfide back into usable reduced glutathione Key players: Selenium: Essential for the enzyme that initiates the breakdown of hydrogen peroxide Riboflavin (FAD - coenzyme form of riboflavin): essential for the enzyme that restores the oxidized Glutathione back to its more useful state

[DOI] [PMC free article] [PubMed] [Google Scholar] 177.Mead BP, Curley CT, Kim N, Negron K, Garrison WJ, Song J, Rao D, Miller GW, Mandell JW, Purow BW, Suk JS, Hanes J, Price RJ

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